How long does it take for Pregabalin to work?

Pregabalin, this relatively new drug first stated in 2004 with Pfizer on the regulatory status of it, then obtained approval from the FDA (Food and Drug Administration) for the treatment for neuropathic pain on the last day of 2004.

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Pregabalin

In 2007, FDA approved Pregabalin as the first drug for the management of fibromyalgia.

In 2012, it approved Pregabalin for controlling the neuropathic pain (damage or disease affecting a part of the sensory nervous system called the somatosensory system which causes pain in the nerves) caused by spinal cord injury.

And the successes continue when the FDA approved Pregabalin extended-release tablets for neuropathic pain conditions in 2017.

Pregabalin is also used for postherpetic neuralgia (severe pain sensed as stabbing or burning sensation caused by the irritating or damaged nerve), and as adjunctive therapy in treating partial-onset seizures.

And if we are going to talk about the successes of Pregabalin, we have to talk about how long does it take for Pregabalin to work?

Pregabalin is a fast-acting drug with high absorption after oral administration.

How to use Pregabalin?

Before taking any medication, you have to read the medication guide carefully.

If you have any inquiries, consult with your health care professional.

This is an orally available drug only.

It is not available as neither injectable nor rectal forms.

The dosage is based on the age and weight of the patient, medical condition, kidney function, and response to treatment.

If you are using the oral solution, use a special measuring device or spoon, don’t use a household spoon as it may give an incorrect dose which affects the effect of the drug.

You should start the medication with a low dose, then the physician can increase the dose as needed till reaches the lowest effective dose.

The dose must be taken at the same times every day to ensure a constant level of Pregabalin to make sure that the patient takes the most benefit of it.

To take the best on the drug, you have to understand how the drug works and how long does it take for Pregabalin to work?

How does Pregabalin work?

Pregabalin works by slowing down the impulses of the brain causing seizures, that’s how it works as an anti-epileptic drug and as an adjunctive drug to treat partial-onset seizures in adults and children who are 1 month and older.

It also affects the chemicals that send signals for pain through the nervous system, that’s how it works to treat pain caused by fibromyalgia, or the neuropathic pain caused by diabetes, or neuralgia that happens after the infection with herpes zoster, or the pain produced after a spinal cord injury.

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PregabalinLyrica pregabalin 150mg generic
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£107.10
£71.10
Pregabalin

How long does it take for Pregabalin to work?

Pregabalin is a fast-acting drug; the peak of concentration after oral administration happens after 1.5 hours, it has greater than 90% bioavailability (the percentage available to the intended destination) no matter what the dose is.

Pregabalin can be taken with food as food doesn’t affect the total absorption of Pregabalin.

However, it was found that food affects and decreases the concentration in the plasma by 25%-30%.

And also increases the time to reach the peak of the drug to 3 hours approximately.

How long does it take for Pregabalin to work

How long does it take for Pregabalin to work

Contraindications:

Before taking Pregabalin, make sure to inform your doctor if you suffer from any of the following conditions,

  • Lung problems
  • Depression
  • Suicidal thoughts
  • Mood disorder
  • Heart problems
  • Bleeding disorder
  • Kidney problems
  • Diabetes, except you, are taking it to manage the neuropathic pain associated with diabetes
  • Any sort of abuse either drug or alcohol abuse
  • Severe allergic reactions

 

Pregabalin is not approved for:

  • seizures in patients younger than 1-month-old
  • pain caused by fibromyalgia, diabetes, herpes zoster, or spinal cord injury in patients younger than 18 years old
Interactions:

Before taking Pregabalin, you must make sure that you are not taking a drug or food that interacts with it.

Drugs causing serious interactions and you have to use an alternative:

  • benazepril
  • captopril
  • enalapril
  • everolimus
  • fosinopril
  • imidapril
  • lisinopril
  • metoclopramide intranasal
  • moexipril
  • perindopril
  • quinapril
  • ramipril
  • sirolimus
  • temsirolimus
  • trandolapril

 

 

Several drugs need close monitoring while being used with Pregabalin, some of them are:
  • alprazolam
  • amitriptyline
  • amobarbital
  • belladonna and opium
  • benzhydrocodone/acetaminophen
  • buspirone
  • butabarbital
  • carbinoxamine
  • cenobamate
  • cetirizine
  • chloral hydrate
  • chlordiazepoxide
  • chlorpheniramine
  • citalopram
  • codeine
  • diazepam
  • doxepin
  • duloxetine
  • escitalopram
  • eszopiclone
  • ethanol
  • fentanyl
  • midazolam

And many others always tell your doctor about the medications you are taking before taking a new one.

Pregabalin-Alcohol interactions:

Alcohol can increase the side effects of Pregabalin especially those affecting the nervous system, like dizziness, drowsiness, and concentration problems.

We must not also forget about the absorption effect caused by food, so it is preferable to take Pregabalin away from meals.

Pregabalin has many advantages including effectiveness and how long does it take for Pregabalin to work?

Don’t forget to buy Pregabalin from trusted sources such as pharma stores to make sure about the drug you are buying, and also to get the best offers.

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