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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. It may also be used to decrease the risk of colorectal adenomas in people with familial adenomatous polyposis. It is taken by mouth. Benefits are typically seen within an hour.
Common side effects include abdominal pain, nausea, and diarrhea. Serious side effects may include heart attacks, strokes, gastrointestinal perforation, gastrointestinal bleeding, kidney failure, and anaphylaxis. Use is not recommended in people at high risk for heart disease. The risks are similar to other NSAIDs, such as ibuprofen and naproxen. Use in the later part of pregnancy or during breastfeeding is not recommended.
Celecoxib was patented in 1993 and came into medical use in 1999. It is available as a generic medication. A month supply in the United Kingdom costs the NHS less than £2 as of 2019. In the United States, the wholesale cost of this amount is about $US12.90. In 2011, it was one of Pfizer‘s best-selling medications, with $2.5 billion in sales. In 2016, it was the 120th most prescribed medication in the United States with more than 6 million prescriptions
Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, musculoskeletal pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis. It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).
For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol (acetaminophen), which is the first line treatment for osteoarthritis. In knee and hip osteoarthritis, acetaminophen may be ineffective.
Evidence of effects are not clear as a number of studies done by the manufacturer have not been released for independent analysis.