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Buspirone, sold under the brand name Buspar among others, is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder. Benefits support its short term use. It has not been found to be effective in treating psychosis. It is taken by mouth, and it may take up to four weeks for an effect.
Common side effects include nausea, headaches, dizziness, and trouble concentrating. Serious side effects may include hallucinations, serotonin syndrome, and seizures. Use in pregnancy appears to be safe but has not been well studied, while use during breastfeeding is not recommended. How it works is not clear but it is unrelated to benzodiazepines.
Buspirone was first made in 1968 and approved for medical use in the United States in 1986. It is available as a generic medication. A month supply in the United Kingdom costs the NHS about 10 GBP as of 2019. In the United States the wholesale cost of this amount is about US$2.65. In 2016 it was the 90th most prescribed medication in the United States with more than 8 million prescriptions