Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).^[4] It is used for the treatment of obsessive–compulsive disorder, panic disorder, major depressive disorder, and chronic pain.^[4] It may decrease the risk of suicide in those over the age of 65.^[4] It is taken by mouth.^[4]

Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating.^[4] Serious side effects include an increased risk of suicidal behavior in those under the age of 25, seizures, mania, and liver problems.^[4] If stopped suddenly a withdrawal syndrome may occur with headaches, sweating, and dizziness.^[4] It is unclear if it is safe for use in pregnancy.^[4] Its mechanism of action is not entirely clear but is believed to involve increased levels of serotonin.^[4]

Clomipramine was discovered in 1964 by the Swiss drug manufacturer Ciba-Geigy.^[5] It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system.^[6] It is available as a generic medication.^[4] The wholesale price in the developing world is between 0.11 and 0.21 per day as of 2014.^[7] In the United States the wholesale costs as of 2018 is about US$9 per day.^[8] It was made from imipramine

Clomipramine has a number of uses in medicine including in the treatment of:

• Obsessive–compulsive disorder (OCD) which is its only U.S. FDA-labeled indication.^[9][10] Other regulatory agencies (such as the TGA of Australia and the MHRA of the UK) have also approved clomipramine for this indication.^{[11][12][13][14]}
• Major depressive disorder (MDD) a popular off-label use in the US. It is approved by the Australian TGA and the United Kingdom MHRA for this indication.^{[11][12][13][14] [15]} Some have suggested the possible superior efficacy of clomipramine compared to other antidepressants in the treatment of MDD, although at the current time the evidence is insufficient to adequately substantiate this claim.^[16]